CANCER: The lymphoma of the mantle
Mantle lymphoma, or mantle cell lymphoma, is a relatively rare form of lymphoma (6% of non-Hodgkin lymphomas) which in France affects less than 1 000 people each year (three men for one woman and especially after 50 years). That's why we don't know enough about this form of cancer that is the lymphoma of the mantle.
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Characteristics of the mantle lymphoma
To understand what a lymphoma of the mantle is, first of all it is necessary to explain what the mantle is. This is the outer zone of the lymph nodes, the one that surrounds the central part. The mantle of these ganglia is composed of a large number of small lymphocytes (a variety of white blood cells). In the case of mantle lymphoma, a genetic modification (of unknown origin) will lead to the abnormal production of a protein that will promote the development of cancer cells. So it is a form of aggressive cancer that will evolve very quickly.
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Mantle lymphoma Symptoms
The lymphoma of the mantle results in specific symptoms such as an increase in the volume of some lymph nodes, a splenomegaly (the spleen increases in size) or a hepatomegaly (the liver increases in size). Other clinical signs typical of cancers can be observed: high fatigue (asthenia), persistent fever, abnormal weight loss, etc.
Treatment of mantle lymphoma
The prognosis of the mantle's lymphomas is rather dark with little chance of survival at more than 4 years, especially since relapses are numerous. The treatment is based on chemotherapy combined with immunotherapy. If this treatment proves to be effective and the patient is less than 65 years of age, an autograft is carried out (grafting stem cells from the patient itself) to stimulate the production of blood cells that have been destroyed by the treatment at the same Time as cancer cells.
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